Add microRNA to make smooth muscle
نویسندگان
چکیده
منابع مشابه
Endothelial microRNA tells smooth muscle cells to proliferate.
S ince their discovery in the 1990s, many microRNAs (miRs) have been found to control key cellular processes, many of which are relevant to the cardiovascular system. 1 miRs regulate the expression of extensive networks of genes by binding to mRNA molecules in the cytoplasm to inhibit their expression. Therefore, it was quite a surprise when miRs were found in the blood or in the supernatant of...
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The discovery of small noncoding microRNAs (miRNAs) increases the complexity of gene expression regulatory mechanisms. The basic mechanism of miRNA biogenesis and regulatory functions of target genes have been widely elucidated. Recently, it has been recognized that regulation of each step of miRNA biogenesis is critical for generating functional miRNAs. Interestingly, cell signaling pathways, ...
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Airway smooth muscle (ASM) cells play a critical role in the pathophysiology of asthma due to their hypercontractility and their ability to proliferate and secrete inflammatory mediators. microRNAs (miRNAs) are gene regulators that control many signaling pathways and thus serve as potential therapeutic alternatives for many diseases. We have previously shown that miR-708 and miR-140-3p regulate...
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MicroRNA (miR)-146a and miR-146b are negative regulators of inflammatory gene expression in lung fibroblasts, epithelial cells, monocytes, and endothelial cells. The abundance of cyclooxygenase-2 (COX-2) and IL-1β is negatively regulated by the miR-146 family, suggesting miR-146a and/or miR-146b might modulate inflammatory mediator expression in airway smooth muscle thereby contributing to path...
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BACKGROUND Vascular calcification resembles bone formation and involves vascular smooth muscle cell (SMC) transition to an osteoblast-like phenotype to express Runx2, a master osteoblast transcription factor. One possible mechanism by which Runx2 protein expression is induced is downregulation of inhibitory microRNAs (miR). METHODS AND RESULTS Human coronary artery SMCs (CASMCs) treated with ...
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ژورنال
عنوان ژورنال: Nature Reports Stem Cells
سال: 2009
ISSN: 1754-8705
DOI: 10.1038/stemcells.2009.92